EC Number   |
Application |
Reference |
|---|
    1.14.14.176 | drug development |
paclitaxel is a successful anticancer drug |
687790 |
| 1.14.14.176 | medicine |
enzyme may be useful in the biological production of the potent antimitotic drug taxol which shows activity against a range of cancers |
440286, 440288 |
| 1.14.14.176 | synthesis |
engineered biosynthetic pathway for taxane production in Saccharomyces cerevisiae via chromosomal integration of Taxus cuspidata CYP725A4 and CPR genes. When expressed in the Saccharomyces cerevisiae strain, a potential T5alphaol isomer is the predominant product with maximum titers of 24 and 31 mg/l at micro and 1 l bioreactor scale, respectively. Total oxygenated taxane titers are improved to 78 mg/l and the acetylated acetylated T5alpha product is detected with a final titer of 3.7 mg/l |
758950 |
| 1.14.14.176 | synthesis |
expression of taxadiene synthase, taxadiene-5alpha-hydroxylase, and cytochrome P450 reductase in Nicotiana benthamiana. Using a chloroplastic compartmentalized metabolic engineering strategy and enhancement of isoprenoid precursors, the engineered plants can produce taxadiene and taxadiene-5alpha-ol at 56.6 microg/g fresh weight and 1.3 microg /g fresh weight, respectively |
759822 |
