EC Number   |
Application |
Reference |
|---|
   1.14.11.16 | analysis |
isolation of human single-chain Fv fragments directed against human aspartyl-asparaginyl beta-hydroxylase. Antibodies show significant binding to recombinant enzyme in ELISA, tumor cell lines, and tumor tissues. They target different domains of the enzyme. A goat-anti-human IgG saporin conjugate can be delivered into tumor cells by antibody 6-22 and elicits cytotoxicity toward the tumor cells in vitro |
687022 |
| 1.14.11.16 | diagnostics |
the enzyme may have utility as a prognostic biomarker in breast cancer |
765316 |
| 1.14.11.16 | medicine |
ASPH gene alterations have prognostic value both in prostate cancer and castration-resistant prostate cancer patients. ASPH expression promotes a more aggressive malignant phenotype. In castration-resistant prostate cancer cells, inhibition of ASPH expression reduces cell proliferation, invasion and cyclin D1 expression through modulation of the NOTCH signaling. ASPH and HIF1alpha crosstalk might be transiently driven by the oxidative stress evidenced inside castration-resistant prostate cancer cells. ASPH silencing leads to increased phosphorylation of GSK3beta |
764407 |
| 1.14.11.16 | medicine |
biomarker to prognosticate non-small cell lung cancer |
698195 |
| 1.14.11.16 | medicine |
insulin-like growth factor-1 stimulates peptide-aspartate beta-dioxygenase protein expression and directional motility. Ethanol reduces the stimulation without inhibition of the mRNA expression, and phosphorylation of the enzyme is higher in ethanol-treated compared with control cells |
684228 |
| 1.14.11.16 | medicine |
insulin/IGF-1 stimulation of asparaginyl-beta-hydroxylase and Notch are enhanced by inhibiting kinases that could phosphorylate asparaginyl-beta-hydroxylase protein. Targeted manipulation of the phosphorylation state of asparaginyl-beta-hydroxylase may have therapeutic value for reducing asparaginyl-beta-hydroxylase-Notch activation and attendant infiltrative growth of hepatocellular carcinomas |
743130 |
| 1.14.11.16 | medicine |
isolation of human single-chain Fv fragments directed against human aspartyl-asparaginyl beta-hydroxylase. Antibodies show significant binding to recombinant enzyme in ELISA, tumor cell lines, and tumor tissues. They target different domains of the enzyme. A goat-anti-human IgG saporin conjugate can be delivered into tumor cells by antibody 6-22 and elicits cytotoxicity toward the tumor cells in vitro |
687022 |
