EC Number   |
Application |
Reference  |
|---|
    4.4.1.20 | drug development |
leukotrienes are an important therapeutic target in asthma and inflammatory diseases |
665848 |
| 4.4.1.20 | molecular biology |
TNF-alpha exposure downregulates the LTC4 synthase gene expression in monocytes/macrophages via a transcriptional mechanism |
677457, 677480 |
| 4.4.1.20 | molecular biology |
transient transfection into human monocytic leukemia (THP-1), rat basophilic leukemia (RBL-1), and human embryonic kidney (HEK293/T) epithelial cells show that eGFP was expressed by cells which express leukotriene C4 synthase (RBL-1 and THP-1) but not by the leukotriene C4 synthase negative HEK293/T cells |
677985 |
| 4.4.1.20 | medicine |
sodium nitroprusside inhibits leukotriene C4 synthase activity and dwonregulates the protein expression of the enzyme |
-, 678098 |
| 4.4.1.20 | medicine |
aspirin induced urticaria aggregates in families inheriting the LTC4S -444C allele |
678958 |
| 4.4.1.20 | medicine |
damaged or inflamed bronchial epithelium may synthesize leukotrienes that contribute directly to bronchoconstriction and leucocytosis in airway inflammation, LTC4 synthase is constitutively expressed in primary bronchial epithelial cells and in the 16-HBE 14o-cell line |
679295 |
| 4.4.1.20 | molecular biology |
the third hydrophobic region, containing a putative transmembrane helix, acts as a nuclear envelope localization signal and is involved in the homooligomerization of LTC4S |
681027 |
| 4.4.1.20 | medicine |
aspirin desensitization may provide effective therapy for aspirin-exacerbated respiratory disease, at least in part, through mitigation of STAT6 expression, thereby downregulating LTC4S pathways |
708859 |
| 4.4.1.20 | medicine |
the C allele of the A-444C polymorphism is a risk factor for aspirin-induced urticaria in a Venezuelan population and may be a genetic marker for this phenotype. This single-nucleotide polymorphism is mainly associated with the cutaneous clinical pattern and with low skin response to histamine |
709410 |
| 4.4.1.20 | medicine |
(-1072)GNA and (-444)ANC promoter polymorphisms of LTC4 synthase influence risk of transient ischemic attack and ischemic stroke, but not risk of ischemic heart disease/coronary atherosclerosis, asthma, or chronic obstructive pulmonary disease in a Danish population. The (-1072)A allele has a frequency of 0.07 while the (-444)C allele has a frequency of 0.29. The (-1072)A and (-444)C alleles are on different haplotypes, thus one polymorphism cannot tag the other. Genetically altered leukotriene C4 synthase activity may play a role in thrombi formation rather than the development of atherosclerosis |
709560 |
