EC Number |
Application |
Reference |
---|
3.7.1.4 | medicine |
adult-type hypolactasia is characterized by a fall of lactase activity levels to 5 - 10% of birth levels occuring during childhood and adolescence |
685892 |
3.7.1.4 | medicine |
adult-type hypolactasia results from the progressive decline of lactase-phlorizin hydrolase activity in enterocytes after weaning, lactase nonpersistence may determine a primary lactose intolerance with reduced diary product consumption, which is possibly related to an increased risk of colon cancer |
687838 |
3.7.1.4 | medicine |
hypolactasia seems to be strongly corretated with genotype C/C of the genetic variant C->T-13910 upstream of the lactase-phlorizin hydrolase gene |
673123 |
3.7.1.4 | medicine |
rapid genotyping assay for LPH-13910 polymorphism based on real-time PCR, which may assist in differentiating patients with primary hypolactasia from those with secondary hypolactasia and lactose intolerance |
673123 |
3.7.1.4 | molecular biology |
98% similarity of the rabbit LPH precursor to PNGH sequence, LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing |
671823 |
3.7.1.4 | molecular biology |
cell specificty of LPH gene expression depends upon both positive and negative interactions among elements in the first 2kb of the LPH 5'-flanking region, generally positive activity between -74 and -37 bp, a cell-specific negative region between -210 and -95 bp, and additional elements further toward the 5' terminus that confer a highly cell-specific response in reporter activity, potential binding sites for various intestinal transcription factors, binding of HNF3beta at three sites is relevant to LPH expression |
675587 |
3.7.1.4 | molecular biology |
LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing |
671823 |