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Results 1 - 6 of 6
EC Number
Application
Commentary
Reference
medicine
adult-type hypolactasia is characterized by a fall of lactase activity levels to 5 - 10% of birth levels occuring during childhood and adolescence
medicine
adult-type hypolactasia results from the progressive decline of lactase-phlorizin hydrolase activity in enterocytes after weaning, lactase nonpersistence may determine a primary lactose intolerance with reduced diary product consumption, which is possibly related to an increased risk of colon cancer
medicine
hypolactasia seems to be strongly corretated with genotype C/C of the genetic variant C->T-13910 upstream of the lactase-phlorizin hydrolase gene; rapid genotyping assay for LPH-13910 polymorphism based on real-time PCR, which may assist in differentiating patients with primary hypolactasia from those with secondary hypolactasia and lactose intolerance
molecular biology
98% similarity of the rabbit LPH precursor to PNGH sequence, LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing
molecular biology
cell specificty of LPH gene expression depends upon both positive and negative interactions among elements in the first 2kb of the LPH 5'-flanking region, generally positive activity between -74 and -37 bp, a cell-specific negative region between -210 and -95 bp, and additional elements further toward the 5' terminus that confer a highly cell-specific response in reporter activity, potential binding sites for various intestinal transcription factors, binding of HNF3beta at three sites is relevant to LPH expression
molecular biology
LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing
Results 1 - 6 of 6