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Results 1 - 10 of 23 > >>
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine 2-chloroacetamidine may potentially find wide applicability as a general pharmacophore, useful in delineating characteristics of the amidinotransferase superfamily 664074
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine DDAH activity and elevated endogenous asymmetric dimethylarginine is implicated in endothelial dysfunction exposed to glycosylated bovine serum albumin, aminoguanidine can protect endothelium against injury induced by glycosylated bovine serum albumin both in vitro and in vivo 667365
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine DDAH influences insulin sensitivity by regulating the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine 695944
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18more DDAH1 plays an important role in development 668120
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine decreased DDAH-1 expression may cause accumulation of endogenous inhibitors of enothelial NO synthase, thereby contributing to endothelial dysfunction in the failing heart 667155
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18more dimerization is not critical for the maintenance of the biological function of the protein 652942
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (hydrolyzed by DDAH) is elevated in many patients and may contribute to the initiation and progression of their disease 667159
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine epoetin beta and darbepoetin alpha posttranslationally impair DDAH activity via increased oxidative stress, causing NG,NG-dimethyl-L-arginine as an important cardiovascular risk factor to accumulate and inhibit NO-synthesis 669059
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine expression and secretion of the vascular endothelial growth factor is not increased in DDAH1-transfected cells 667355
Display the word mapDisplay the reaction diagram Show all sequences 3.5.3.18medicine global knockout of Ddah2 results in elevated blood pressure during periods of activity and changes in vascular responsiveness mediated by changes in methylarginine concentration, and systemic nitric oxide concentrations. In a model of severe polymicrobial sepsis, Ddah2 knockout affects outcome. Monocyte-specific deletion of Ddah2 results in a similar pattern of increased severity to that seen in globally deficient animals 752613
Results 1 - 10 of 23 > >>