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Results 1 - 4 of 4
EC Number
Application
Commentary
Reference
drug development
cruzipain is an attractive target for the development of novel trypanocidal drugs
medicine
CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR; CatL-like sequences are excellent targets for diagnosis and genotyping of Trypanosoma rangeli by PCR
molecular biology
in this study it is shown in murine macrophage cell line J774 as well as in murine bone marrow-derived macrophages, that cruzipain induces p38 phosphorylation with Trypanosoma cruzi infection triggering mainly JNK and ERK phosphorylation. Cruzipain also favors the survival in macrophages by changing the iNOS/arginase balance
pharmacology
induction of RNAi against brucipain of Trypanosoma brucei does not cure mice from infection, however, 50% of these mice survive 60 days longer than uninduced controls. The ability of Trypanosoma brucei to cross an in vitro model of the human blood-brain barrier is also reduced by brucipain RNAi induction
Results 1 - 4 of 4