EC Number   |
Application |
Reference |
|---|
   3.4.21.78 | medicine |
both GzmA and GzmB levels are significantly increased in serum of patients with patients with amyotrophic lateral sclerosis |
717504 |
| 3.4.21.78 | medicine |
construction of a chimeric protein IGA, consisting of interleukin IL-2 and granzyme A, using IL-2 as a targeting moiety and granzyme A as a killing moiety to overcome multidrug resistance MDR in anticancer therapy. The IGA chimeric protein enters the target sensitive and MDR cancer cells overexpressing IL-2 receptor and induces caspase 3-independent cell death. After its entry, IGA causes a decrease in the mitochondrial potential, and triggers translocation of nm23-H1, a granzyme A-dependent DNase, from the cytoplasm to the nucleus, where it causes single-strand DNA nicks, thus causing cell death. IGA is able to overcome MDR and kill cells resistant to chemotherapeutic drugs |
717675 |
| 3.4.21.78 | medicine |
cytolytic T-lymphocytes from enzyme or granzyme B deficient mice similarly induce early proapoptotic features such as phosphatidyl serine exposure on plasma membrane, or reactive oxygen radical generation, though with distinct kinetics. Cytolytic T-lymphocytes from granzyme A, but not granzyme B deficient animals activate caspase 3 and 9. All granzyme-induced apoptotic features depend critically on perforin |
665795 |
| 3.4.21.78 | medicine |
diagnosis tool, patients with various viral diseases or with rheumatic arthritis have elevated levels of circulating granzyme A |
650720 |
| 3.4.21.78 | medicine |
granzyme A is located in intracellular granules of rectal CD8+ T cells in healthy and HIV-1-positive individuals, while similar amounts of perforin RNA are detected in both groups, but perforin protein is absent in rectal tissue of HIV-1-positive individuals |
665914 |
| 3.4.21.78 | medicine |
investigation of glucocorticoid-induced expression of granzyme A as a potential early biomarker for personalized therapy of acute lymphoblastic leukemia patients |
683723 |
| 3.4.21.78 | medicine |
involvement of granzyme A in development of chronic obstructive pulmonary disease (COPD) shown, increased expression of granzyme A in type II pneumocytes indicated |
683058 |
| 3.4.21.78 | medicine |
involvement of granzyme A in development of chronic obstructive pulmonary disease shown |
683058 |
| 3.4.21.78 | medicine |
involvement of granzyme A in development of chronic obstructive pulmonary disease shown, increased expression of granzyme A in type II pneumocytes |
683058 |
| 3.4.21.78 | medicine |
proinflammatory gzmA and anti-inflammatory gzmB are novel modulators of the Th1/2 balance and defense in helminth infection |
717939 |
