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Results 1 - 8 of 8
EC Number
Application
Commentary
Reference
medicine
a series of experiments demonstrates the capacity of the longer acting mutant, CocE T172R/G173Q, to provide a long-lasting protection against cocaine-induced convulsion and lethality, and a dose-dependent and selective inhibition the ongoing self-administration of cocaine in rats. Potential usefulness of a suitable, stable, and long-acting form of CocE as a pharmacotherapy for cocaine abuse in humans
medicine
because of the high catalytic proficiency of cocE, it is an attractive candidate for novel protein-based therapies for cocaine overdose
medicine
cocaine esterase is used to accelerate the removal of systemic cocaine and to prevent cocaine-induced lethality
medicine
cocaine esterase is used to accelerate the removal of systemic cocaine and to prevent cocaine-induced lethality; the wild type cocaine esterase cannot be used as a pharmacotherapy for cocaine abuse because of its 13.7-min half-life at 37°C
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medicine
CocE produces robust protection and reversal of cocaine toxicity and provides in vivo evidence for the therapeutic potential of CocE in the treatment of acute cocaine toxicity. Repeated use of CocE may gradually reduce the effectiveness of CocE as a protection or rescue treatment due to the production of anti-CocE antibodies
medicine
enhancing cocaine metabolism by administration of cocaine esterase (CocE) is a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine. A major obstacle to the clinical application of CocE is the thermoinstability of native CocE with a half-life of only a few min at physiological temperature. Computational-experimental effort yields a CocE variant with a 30fold increase in plasma half-life both in vitro and in vivo
medicine
the high catalytic proficiency, lack of observable product inhibition, and ability to hydrolyze both cocaine and cocaethylene make cocE an attractive candidate for rapid cocaine detoxification in an emergency setting
medicine
the wild type cocaine esterase cannot be used as a pharmacotherapy for cocaine abuse because of its 13.7-min half-life at 37°C
Results 1 - 8 of 8