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EC Number Application Commentary Reference
Show all pathways known for 2.7.4.14Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.14medicine screening of acyclic phosphonate analogs to find antimetabolites for antivirus and anticancer therapies 673598
Show all pathways known for 2.7.4.14Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.14diagnostics UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer. Analysis of 461 breast adenocarcinoma samples, overview. While cytoplasmic CMPK1 does not show any association to metastasis free survival (MFS), nuclear CMPK1 is associated to poor prognosis independently from other prognostic factors in stratified Cox regression analyses 739700
Show all pathways known for 2.7.4.14Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.14medicine lipopolysaccharide-induced human chorionic trophoblast HTR8/SVneo cell model to mimic missed abortion in vitro. CMPK2 expression and NLRP3 inflammasome activation, downstream pro-IL-18 and pro-IL-1beta expression, and IL-18 and IL-1beta release, are all significantly increased in missed abortion tissues or LPS-induced HTR8/SVneo cells. Pigment epithelium-derived factor reverses the increase in CMPK2 expression and activation of the NLRP3 inflammasome axis and downregulates the production of mitochondrial reactive oxygen species and mitochondrial DNA release 761290
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