EC Number   |
Application  |
Reference |
|---|
   1.6.3.5 | medicine |
in chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples and is also widely present in pancreatic ductal adenocarcinoma precursor lesions and pancreatic ductal adenocarcinoma tissue. Among 240 patients with pancreatic ductal adenocarcinoma, elevated plasma renalase levels are associated with worse tumor characteristics, including greater angiolymphatic invasion and greater node positive disease. Overall survival is worse in patients with high plasma renalase levels. Renalase levels also predict whether patients with locally advanced/borderline resectable pancreatic ductal adenocarcinoma undergo resection |
765662 |
| 1.6.3.5 | medicine |
plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects |
728036 |
| 1.6.3.5 | medicine |
renalase deficiency is associated with increased renal dopamine synthesis, stimulated phosphate excretion, and moderately severe hypophosphatemia. The signal to increase renal dopamine synthesis is strong since it overcomes a compensatory increase in catechol-O-methyl transferase activity |
726659 |
| 1.6.3.5 | medicine |
renalase infusion in rats causes a decrease in cardiac contractility, heart rate, and blood pressure and prevents a compensatory increase in peripheral vascular tone |
728036 |
| 1.6.3.5 | medicine |
renalase is a cardiovascular drug for ischemia/ischemia reperfusion injury |
743188 |
| 1.6.3.5 | medicine |
renalase levels are significantly lower in schizophrenia patients than in the control group, whereas dopamine levels are significantly higher. The epinephrine levels of both groups are similar, while the norepinephrine levels in patients with schizophrenia are significantly lower than those in the control group |
765214 |
