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plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects
renalase deficiency is associated with increased renal dopamine synthesis, stimulated phosphate excretion, and moderately severe hypophosphatemia. The signal to increase renal dopamine synthesis is strong since it overcomes a compensatory increase in catechol-O-methyl transferase activity
renalase infusion in rats causes a decrease in cardiac contractility, heart rate, and blood pressure and prevents a compensatory increase in peripheral vascular tone
renalase is a cardiovascular drug for ischemia/ischemia reperfusion injury
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