EC Number   |
Application  |
Reference |
|---|
   1.4.4.2 | diagnostics |
expression of HIF-1alpha and glycine decarboxylase (GLDC) are associated with shorter tumor-related survival, although not independent from each other. The combination of GLDC and HIF-1alpha expression emerges as an independent prognostic factor in in early-stage lung non-small cell cancer (NSCC) |
765869 |
| 1.4.4.2 | diagnostics |
high glycine decarboxylase expression is associated with poor prognosis and advanced stages of neuroblastoma. MYCN amplification is a biomarker for glycine decarboxylase-based therapeutic strategies against high-risk neuroblastoma |
765486 |
| 1.4.4.2 | medicine |
in eight-week-old Zucker diabetic fatty rats (ZDF, a type-II diabetic animal model) receiving either 1% glycine or 1.19% L-alanine in drinking water for 6 weeks, glycine concentrations in serum and liver are markedly lower than in a group of control lean Zucker rats. Enteral glycine supplementation restores both serum and hepatic glycine levels, while reducing mesenteric and internal white fat mass compared with alanine-treated Zucker diabetic fatty rats rats. Blood glucose and non-esterified fatty acid concentrations do not differ between the control and glycine-supplemented Zucker diabetic fatty rats rats. Both mRNA and protein expression of aminomethyltransferase and decarboxylating glycine dehydrogenase are increased in the livers of obese versus lean rats. In contrast, glycine cleavage system H hepatic mRNA expression is downregulated in obese versus lean rats |
762597 |
| 1.4.4.2 | medicine |
mutations of the glycine decarboxylase gene are found in patients with nonketotic hyperglycinemia, NKH |
676168 |
| 1.4.4.2 | medicine |
serum GLDC is associated with increased lung cancer risk. Years of smoking are associated with serum GLDC in patients with lung cancer. The association is attenuated in the serum of matched controls. Overexpression of GLDC protein contributes to malignant transformation and inhibits microRNA-29 family expression in normal human bronchial epithelial cells |
763473 |
| 1.4.4.2 | more |
GDC is dispensable for cyanobacterial metabolism |
676615 |
| 1.4.4.2 | more |
GDC is not necessary for cell viability under standard conditions. GDC is dispensable for Synechocystis |
676396 |
