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matrix metalloproteinase MT1-MMP physically interacts with claudin-1 and acireductone dioxygenase 1, both associated with hepatitis C virus cell entry. Positive cytoplasmic ADI1 in liver biopsies is associated with higher serum hepatitis C virus RNA levels. Positive MT1-MMP and ADI1 interaction is associated with lower tissue hepatitis C virus RNA levels. Hepatic hepatitis C virus RNA levels are positively associated with ADI1 levels in the MT1-MMP and ADI1 coimmunoprecipitates
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