EC Number   |
Natural Substrates |
|---|
   7.6.2.1 | ATP + H2O |
- |
| 7.6.2.1 | ATP + H2O |
selectively pumps the aminophospholipids phospatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane |
| 7.6.2.1 | ATP + H2O |
down-regulation of the aminophospholipid translocase activity is an early step in the programmed cell death in lymphocytes, a step that contributes to the appearance of phosphatidylserine on the cell surface as a recognition signal for phagocytosis |
| 7.6.2.1 | ATP + H2O |
the enzyme plays an important role in the maintenance of membrane phospholipid asymmetry, observed in plasma membrane and membranes of certain cellular organelles |
| 7.6.2.1 | ATP + H2O |
the initial maintenance of phospholipid asymmetry in diamide-treated erythrocytes can be solely ascribed to the action of the ATP-dependent aminophospholipid translocase |
| 7.6.2.1 | ATP + H2O |
role in aminophospholipid transport |
| 7.6.2.1 | ATP + H2O |
role of the enzyme in the control of erythrocyte shape, possibly through association with the ATP-dependent translocation of phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the bilayer |
| 7.6.2.1 | ATP + H2O |
phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate. Without phosphatidylserine, ATPase II accumulates as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle |
| 7.6.2.1 | ATP + H2O |
the enzyme is responsible for the inward transport of phosphatidylserine and phosphatidylethanolamine within the erythrocyte membrane |
| 7.6.2.1 | ATP + H2O + aminophospholipid[side 1] |
- |
