EC Number   |
Natural Substrates |
|---|
   7.2.2.21 | ATP + H2O + Cd2+/in |
- |
| 7.2.2.21 | ATP + H2O + Cd2+/in |
active transport of Cd2+ out of the cell to maintain metal homeostasis |
| 7.2.2.21 | ATP + H2O + Cd2+/in |
Pca1 plays a critical role in cadmium resistance by extruding intracellular cadmium. Yeast cells rapidly enhance expression of Pca1 by a post-transcriptional mechanism. In the absence of cadmium, Pca1 is targeted for degradation before reaching the plasmamembrane |
| 7.2.2.21 | ATP + H2O + Zn2+/in |
active transport of Cd2+ out of the cell to maintain metal homeostasis |
| 7.2.2.21 | more |
involved in Cd2+, Pb2+, and Zn2+ resistance |
| 7.2.2.21 | more |
involved in Cd2+, Pb2+, and Zn2+ resistance, not involved in Hg2+ resistance |
| 7.2.2.21 | more |
cadmium and zinc lead to the upregulation of genes encoded on the pSymA or pSymB plasmids, expression of the efflux pumps SMc01095, i.e. mexF1, and SMb20345 is enhanced 41fold and 4fold, respectively, overview |
| 7.2.2.21 | more |
mechanism for substrate-mediated control of P1B-type ATPase expression, overview. Dependence of Pca1 degradation through the vacuolar/endosomal pathway |
