EC Number |
Natural Substrates |
---|
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + CO2 |
- |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + CO2 |
biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin and is one component of the multienzyme complex acetyl-CoA carboxylase that catalyzes the first committed step in fatty acid synthesis |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + CO2 |
The overall acetyl-CoA carboxylase, ACC, reaction proceeds by a two-step mechanism. The first half-reaction is carried out by the biotin carboxylase and involves the ATP-dependent carboxylation of biotin, in which bicarbonate serves as the CO2 source. The carboxyl transferase catalyzes the second half-reaction in which the carboxyl group is transferred from biotin to acetyl-CoA to produce malonyl-CoA, the biotinoyl domain performs a critical function by transferring the activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, overview |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
- |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
biosynthesis of long-chain fatty acids, in vivo biotin is attached to the carboxyl-carrier protein through an amide bond to a specific lysine residue |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
biotin carboxylase catalyzes the first half-reaction in the first committed step in long chain fatty acid biosynthesis, catalyzed by acetyl-CoA carboxylase |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
first half reaction of the first committed step in the biosynthesis of long-chain fatty acids, in vivo the biotin substrate is attached to biotin-carboxyl-carrier protein, natural substrate |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
long-chain fatty acid synthesis, in vivo biotin is covalently attached to the biotin-carboxyl-carrier protein |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
long-chain fatty acid synthesis, in vivo biotin is linked to the biotin-carboxyl-carrier protein through an amide bond to a specific lysine residue |
6.3.4.14 | ATP + biotin-carboxyl-carrier protein + HCO3- |
one component of the multienzyme complex acetyl-CoA carboxylase, catalyzes the ATP-dependent carboxylation of biotin, which is covalently attached to the biotin-carboxyl-carrier protein in vivo, fatty acid synthesis |