EC Number   |
Natural Substrates |
|---|
    6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
synthesis of trypanothione, which is involved in maintaining intracellular thiol redox and in defense against oxidants |
| 6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
key enzyme that participates in the first of two similar steps of trypanothione biosynthesis |
| 6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
the enzyme is involved in the biosynthesis of the trypanosomatid-specific dithiol trypanothione |
| 6.3.1.8 | glutathione + spermidine + ATP |
- |
| 6.3.1.8 | glutathione + spermidine + ATP |
trypanothione synthase |
| 6.3.1.8 | glutathione + spermidine + ATP |
trypanothione synthase catalyzes both the reaction of glutathionylspermidine synthase, EC 6.3.1.8, and of trypanothione synthase, EC 6.3.1.9, in Trypanosoma brucei |
| 6.3.1.8 | glutathione + spermidine + ATP |
glutathionylspermidine is an intermediate formed in the biosynthesis of trypanothione, an essential metabolite in defence against chemical and oxidative stress in the kinetoplastida |
| 6.3.1.8 | more |
important reaction in defense against chemical and oxidant stress, thiol redox homeostasis, ribonucleotide metabolism, and drug resistance in parasitic kinetoplastids |
| 6.3.1.8 | more |
the enzyme is important for several functions, e.g. for detoxification of H2O2 and organic hyperoxids, and ribonucleotide reduction |
| 6.3.1.8 | more |
the trypanothione synthase also converts glutathionylspermidine further to trypanothione catalyzing the reaction of EC 6.3.1.9 |
