EC Number   |
Natural Substrates |
|---|
   6.2.1.54 | ATP + D-alanine + poly(ribitol phosphate) |
- |
| 6.2.1.54 | ATP + D-alanine + poly(ribitol phosphate) |
the biosynthesis of D-alanyl-lipoteichoic acid requires four proteins that are encoded by the dlt operon. The synthesis starts with the selection of the D-Ala by the 57000 Da D-Ala-D-Ala carrier protein ligase (DltA). Following activation by DltA, D-Ala is transferred to the 10000 Da D-alanyl carrier protein DltC which can donate D-Ala to lipoteichoic acids with the help of DltB and DltD to mediate the surface charge of the bacterium |
| 6.2.1.54 | D-Alanine + ATP + ? |
biosynthesis of D-alanyl-lipoteichoic acid |
| 6.2.1.54 | more |
the enzyme is required for incorporation of D-alanine in teichoic acids in Gram-positive bacteria, confering resistance to cationic antimicrobial peptides nisin and gallidermin in Streptococcus pneumoniae, enzymes of D-alanine metabolism are encoded in the dltA operon, a functional dlt operon confers resistance to nisin and gallidermin |
