EC Number   |
Natural Substrates |
|---|
    6.1.1.6 | ATP + L-lysine + tRNALys |
- |
| 6.1.1.6 | ATP + L-lysine + tRNALys |
the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm |
| 6.1.1.6 | ATP + L-lysine + tRNALys |
during early assembly of human immunodeficiency virus type 1, an assembly complex is formed, the components of which include genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase. Directly increasing or decreasing cellular expression of LysRS results in corresponding changes in viral infectivity and in the viral concentrations of LysRS, tRNALys, and reverse transcriptase. Overexpression of LysRS in the cell reduces viral protease activity |
| 6.1.1.6 | ATP + L-lysine + tRNALys |
enzyme facilitates the selective packaging of tRNA3 Lys. Newly synthesized LysRS is associated with Gag protein after a 10 minute pulse with [35 S]cysteine/methionine. Incorporation of LysRS into HIV-1 is very sensitive to the inhibition of new synthesis of LysRS |
| 6.1.1.6 | ATP + L-lysine + tRNALys |
the enzyme is secreted to trigger proinflammatory response. TNF-alpha induces secretion of lysyl-tRNA synthetase. The secreted enzyme binds to macrophages and peripheral blood mononuclear cell to enhance the TNF-alpha production and their migration. The mitogen-activated protein kinases, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and inhibitory protein Galphai are involved in the signal transduction triggered by lysyl-tRNA synthetase. Lysyl-tRNA synthetase may work as a signaling molecule, inducing immune response through the activation of monocyte/macrophages |
| 6.1.1.6 | ATP + lysine + tRNALys |
- |
| 6.1.1.6 | ATP + lysine + tRNALys |
the enzymes major function is to provide Lys-tRNALys fpr protein biosynthesis |
| 6.1.1.6 | ATP + lysine + tRNALys |
primary role is the translation of genetic information into protein structure |
| 6.1.1.6 | more |
aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I |
| 6.1.1.6 | more |
enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview |
