EC Number   |
Natural Substrates |
|---|
    6.1.1.22 | ATP + L-asparagine + tRNAAsn |
- |
| 6.1.1.22 | more |
the high level of asparaginyl-tRNA synthetase expression reflects unusual metabolic demands associated with larval maturation |
| 6.1.1.22 | more |
human cytoplasmic aminoacyl-tRNA synthetases, which are autoantigens in idiopathic inflammatory myopathies, activate chemokine receptors on T lymphocytes, monocytes, and immature dendritic cells by recruiting immune cells that could induce innate and adaptive immune responses |
| 6.1.1.22 | more |
the parasite Brugia malayi enzyme, in analogy to the human enzyme, induces human leukocyte chemotaxis and activates G-protein-coupled receptors CXCR1 and CXCR2, but not CXCR3, filarial asparaginyl-tRNA synthetase, AsnRS, is known to be an immunodominant antigen that induces strong human immunoglobulin G3 responses and contributes to the development of chronic inflammatory disease such as lymphatic filariasis, overview |
