EC Number   |
Natural Substrates |
|---|
   5.3.4.1 | alkaline protease inhibitor |
folding and rearrangement of alkaline protease inhibitor |
| 5.3.4.1 | apolipoprotein B100 |
the enzyme assists in the oxidative folding of apolipoprotein B100 |
| 5.3.4.1 | beta-actin |
- |
| 5.3.4.1 | carboxypeptidase Y |
maturation of carboxypeptidase Y |
| 5.3.4.1 | denatured RNase A + GSH |
- |
| 5.3.4.1 | E2A homodimer |
PDI I and PDI II foster heterodimer formation between E proteins, i.e. basic-loop-helix proteins of the E2A gene products, by a redox mechanism |
| 5.3.4.1 | estrogen receptor alpha |
i.e. ERalpha, PDI plays a critical role in estrogen responsiveness by functioning as a molecular chaperone and assisting the receptor in differentially regulating target gene expression, PDI alters estrogen-mediated transactivation, overview, PDI enhances ERalpha-DNA interactions in presence of an oxidizing agent |
| 5.3.4.1 | glutathione disulfide |
- |
| 5.3.4.1 | HED-SSM |
a mixed disulfide |
| 5.3.4.1 | Insulin-(SS) + GSH |
- |
