EC Number   |
Natural Substrates |
|---|
    4.1.1.32 | GDP + phosphoenolpyruvate + CO2 |
- |
| 4.1.1.32 | GDP + phosphoenolpyruvate + CO2 |
highest activity |
| 4.1.1.32 | GTP + oxaloacetate |
- |
| 4.1.1.32 | GTP + oxaloacetate |
catalyzes the first committed step in gluconeogenesis, in vivo enzyme prefers the gluconeogenesis/glycerogenesis direction, i.e phosphoenolpyruvate formation, GDP is the more physiologically relevant nucleotide substrate than IDP |
| 4.1.1.32 | GTP + oxaloacetate |
catalyzes the rate-limiting step in gluconeogenesis |
| 4.1.1.32 | GTP + oxaloacetate |
catalyzes the rate-limiting step in gluconeogenesis, PEPCK expression and growth arrest may be coordinately regulated |
| 4.1.1.32 | GTP + oxaloacetate |
catalyzes the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle |
| 4.1.1.32 | GTP + oxaloacetate |
committed step in gluconeogenesis |
| 4.1.1.32 | GTP + oxaloacetate |
decarboxylation of oxaloacetate is the physiological important reaction |
| 4.1.1.32 | GTP + oxaloacetate |
key enzyme involved in the regulation of gluconeogenesis |
