EC Number |
Natural Substrates |
---|
4.1.1.28 | 3,4-Dihydroxyphenylalanine |
neuroprotective role for AADC against L-DOPA toxicity in primary striatal cultures. The protective effect is due primarily to AADC-dependent conversion of L-DOPA to dopamine, leading, in turn, to an increase in intracellular dopamine levels |
4.1.1.28 | 3,4-Dihydroxyphenylalanine |
enzyme is involved in the biosynthesis of monoamine neurotransmitters |
4.1.1.28 | 3,4-Dihydroxyphenylalanine |
L-DOPA, substrate exerts apoptotic cytotoxicity towards PC12 cells at a concentration of 0.1-0.2 mM for 24-48 h |
4.1.1.28 | 3,4-dihydroxyphenylalanine |
regulation of the ganglionic dopamine level |
4.1.1.28 | 5-hydroxy-L-tryptophan |
- |
4.1.1.28 | 5-Hydroxytryptophan |
- |
4.1.1.28 | 5-Hydroxytryptophan |
The biosynthesis of serotonin requires aromatic substrates to be bound in the active sites of the enzymes tryptophan hydroxylase and aromatic amino acid decarboxylase |
4.1.1.28 | L-3,4-Dihydroxyphenylalanine |
- |
4.1.1.28 | L-3,4-Dihydroxyphenylalanine |
L-dopa |
4.1.1.28 | L-3,4-Dihydroxyphenylalanine |
DOPA, plays a role in the neuromodulation of behavior |