EC Number   |
Natural Substrates |
|---|
   3.6.1.55 | 8-oxo-dGDP + H2O |
- |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
- |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
8-oxoguanine (8-oxo-7,8-dihydroguanine) is produced in nucleic acids as well as in nucleotide pools of cells, by reactive oxygen species normally formed during cellular metabolic processes. MutT protein of Escherichia coli specifically degrades 8-oxoGua-containing deoxyribo- and ribonucleoside triphosphates to corresponding nucleoside monophosphates, thereby preventing misincorporation of 8-oxoguanine into DNA and RNA, which would cause mutation and phenotypic suppression, respectively |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
the MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP), which are otherwise incorporated in DNA and RNA opposite template A. This cleaning of the nucleotide pools decreases both DNA replication and transcription errors |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
the oxidized nucleotide precursors 8-oxo-dGTP is readily incorporated into nascent DNA strands during replication, which would cause base substitution mutations. 8-oxo-dGTP diphosphatase (8-oxo-dGTP diphosphatase) enzyme has the potential to prevent mutations by 8-oxo-dGTP in Ciona intestinalis |
| 3.6.1.55 | 8-oxo-GDP + H2O |
- |
