EC Number   |
Natural Substrates |
|---|
   3.6.1.29 | adenosine 5'-phosphoramidate + H2O |
- |
| 3.6.1.29 | adenosine 5'-phosphoramidate + H2O |
no requirement for Mg2+ |
| 3.6.1.29 | adenosine 5'-phosphosulfate + H2O |
no requirement for Mg2+, reaction of EC 3.6.2.1, adenylylsulfatase |
| 3.6.1.29 | adenosine 5'-phosphosulfate + H2O |
reaction of EC 3.6.2.1, adenylylsulfatase |
| 3.6.1.29 | adenylylfluoride + H2O |
- |
| 3.6.1.29 | gamma-fluoro-ATP + H2O |
- |
| 3.6.1.29 | more |
Fhit is a tumor suppressor protein |
| 3.6.1.29 | more |
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines |
| 3.6.1.29 | more |
diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview |
| 3.6.1.29 | more |
Fhit proteins, in addition to their function as dinucleoside triphosphate hydrolases, act similarly to adenylylsulfatases and nucleoside phosphoramidases, liberating nucleoside 5'-monophosphates from such natural metabolites as adenosine 5'-phosphosulfate and adenosine 5'-phosphoramidate. Moreover, Fhits recognize synthetic nucleotides, such as adenosine 5'-O-phosphorofluoridate and adenosine 5'-O-(gamma-fluorotriphosphate), and release AMP from them, the enzyme is involved in controlling the cellular level of NpnN0', overview |
