EC Number   |
Natural Substrates |
|---|
   3.5.1.97 | more |
virulence of the opportunistic human pathogen is controlled by the N-acyl-homoserine lactone, AHL-dependent quorum-sensing system, the enzyme inactivates AHLs by hydrolysis of the carboxylic side chain with side chain ranging from 11 to 14 C-atoms with broad range specificity, addition of the purified enzyme to cell cultures results in complete inhibition of N-3-oxododecanoyl-(S)-homoserine lactone accumulation and production of the signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone, as well as reduced production of virulence factors elastase and procyanin |
| 3.5.1.97 | more |
N-acyl homoserine lactones, AHLs, with acyl chains ranging from C4 to C14 with or without 3-oxo or 3-hydroxy substituents are all hydrolyzed and inactivated to varying extents, long chain AHLs are generally more susceptible than short chain compounds irrespective of the three position substituent. Ochrobactrum sp. A44 shows a strong preference for inactivating AHLs with the acyl side chains greater than eight carbons and exhibites a slight preference for 3-oxosubstituted AHLs |
| 3.5.1.97 | more |
the enzyme shows a high level of degrading activity against N-acyl-L-homoserine lactones with long acyl chains but no activity against N-acyl-L-homoserine lactones with acyl chains shorter than eight carbons |
| 3.5.1.97 | more |
enzyme MacQ has the bifunctional capacity to degrade both AHL and beta-lactam antibiotics by deacylation activity (cf. EC 3.5.2.6). MacQ is able to inactivate a variety of beta-lactams, including penicillin derivatives (penicillin G, ampicillin, amoxicillin, and carbenicillin) and cephalosporin derivatives (cephalexin and cefadroxil) |
| 3.5.1.97 | more |
the marine bacterium Pseudoalteromonas flavipulchra strain JG1 can degrade N-acylhomoserine lactones (AHLs). PfmA can degrade ampicillin but not penicillin G. The concentration of AHLs in Vibrio anguillarum strain VIB72 and Pseudomonas aeruginosa strain PAO1 is reduced when 0.01 mg/ml PfmA is present |
| 3.5.1.97 | N-3-oxo-decanoyl-L-homoserine lactone + H2O |
- |
| 3.5.1.97 | N-3-oxo-dodecanoyl-L-homoserine lactone + H2O |
- |
| 3.5.1.97 | N-3-oxo-hexanoyl-L-homoserine lactone + H2O |
- |
| 3.5.1.97 | N-3-oxo-octanoyl-L-homoserine lactone + H2O |
- |
| 3.5.1.97 | N-3-oxo-tetradecanoyl-L-homoserine lactone + H2O |
- |
