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Results 1 - 10 of 18 > >>
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15more the enzyme functions in concert with the plasma membrane transporter NaDC3, that specifically transports N-acetylaspartic acid into the cell
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O aspartoacylase is a key enzyme in the human central nervous system. N-Acetyl-L-aspartate is a precursor for the synthesis of the dipeptide N-acetylaspartyl-glutamate, which participates in the neuromodulation of metabotropic and NMDA receptors (NMDA is N-methyl-D-aspartate), regulates the intracellular pressure in neurons and is involved in the energy generation from glutamate anions in neuronal mitochondria. N-Acetyl-L-aspartate is a source of acetyl groups for the construction of myelin sheath in the brain. Therefore, maintenance of the N-acetyl-L-aspartate level ensures proper development and functions of white matter
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O the enzyme hydrolyzes one of the most abundant amino acid derivatives in the brain, N-acetyl-aspartate
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O enzyme mutations cause the Canavan disease
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartate + H2O malfunction of the enzyme causes Canavan disease
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetyl-L-aspartic acid + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetylaspartate + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.15N-acetylaspartate + H2O aspartocylase deficiency results in elevated levels of substrate, brain edema and dysmyelination
Results 1 - 10 of 18 > >>