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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.4.24.7
Collagen + H2O
-
3.4.24.7
collagen I + H2O
degradation
3.4.24.7
collagen III + H2O
degradation
3.4.24.7
Collagen type I + H2O
-
3.4.24.7
Collagen type III + H2O
-
3.4.24.7
Collagen type III + H2O
ability of MMP-1 to unwind triple-helical collagen
3.4.24.7
more
ligation of keratinocyte alpha2beta1 integrin by type 1 collagen induces expression of matrix metalloproteinase-1. The MMP-1 activity is required for the alpha2beta1 integrin-dependent migration of primary keratinocytes across collagenous matrices. MMP-1 binds to the I domain of the alpha2 intergrin subunit
3.4.24.7
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matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt and neuronal death through a non-proteolytic mechanism. MMP-1 might contribute to the neuronal damage which occurs in association with degenerative and inflammatpry conditions characterized by elevated levels of this proteinase
3.4.24.7
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MMP-1 is involved in intestinal re-epithelization in vivo and is upregulated by cytokines relevant in wound repair
3.4.24.7
more
enzyme regulation on expression and protein levels, overview
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