EC Number   |
Natural Substrates |
|---|
   3.4.24.17 | cytosolic protein Apaf-1 + H2O |
- |
| 3.4.24.17 | more |
may play a role in the normal turnover of the connective tissue matrix as well as in the joint destruction of chronic synovitis |
| 3.4.24.17 | more |
believed to play a role in pathological conditions such as arthritis and tumor invasion |
| 3.4.24.17 | more |
glomerular basement membrane degradation by glomeruli may be attributable to stromelysin and suggest an important role for these proteinases in glomerular pathophysiology |
| 3.4.24.17 | more |
degrading all of the major macromolecules of the extracellular matrix |
| 3.4.24.17 | more |
required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling |
| 3.4.24.17 | more |
enzyme attacks the basal lamina and tight junction proteins, opening the blood-brain barrier and thereby facilitating neutrophil influx |
| 3.4.24.17 | more |
enzyme is expressed as a protective response and plays an important role in host defense during squamous cell carcinoma tumorigenesis |
| 3.4.24.17 | more |
genetic ablation of MMP-3 does not significantly affect tumor growth and metastasis in the MMTV-PyMT model |
| 3.4.24.17 | more |
stromelysin (MMP3), through its action on collagen and other matrix metalloproteinases, influences arterial wall remodeling |
