EC Number   |
Natural Substrates |
|---|
   3.4.23.48 | alpha2-antiplasmin + H2O |
Pla inactivates alpha2-antiplasmin |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
alpha2AP is the main inhibitor of free plasmin in the circulation. Pla cleaves and inactivates alpha2AP by a single, rapid cut. It appears likely that the R376-M377 bait peptide bond is targeted by Pla |
| 3.4.23.48 | C3 protein of complement system + H2O |
- |
| 3.4.23.48 | human alpha2-antiplasmin + H2O |
- |
| 3.4.23.48 | more |
plasminogen activator Pla is essential for the spread of Yersinia pestis from the subcutaneous infection site into circulation, and the proteolytic activation of plasminogen is involved in virulence function. In addition to proteolysis plasminogen activator Pla promotes bacterial adhesion to mammalian extracellular matrices and epithelial cells as well as bacterial invasion into eukayotic cells. Laminin functions as an adhesion target for plasminogen activator Pla, which also expresses a lower adhesion affinity for heparan sulfate proteoglycan. the adhesion targets are not directly degraded by plasminogen activator Pla, but Pla-mediated generation of plasmin leads to their degradation |
| 3.4.23.48 | more |
plasminogen activator plays a pivotal role in internalisation of bacteria by HeLa cells. Intracellular signalling and cytoskeletal rearrangement is involved in Yersinia pestis plasminogen activator mediated HeLa cell invasion |
| 3.4.23.48 | more |
the invasion of alveolar macrophages by Yersinia pestis depends both in vitro and in vivo on the expression of plasminogen activator Pla. Macrophages and transfectants expressing C-type lectin receptor DEC-205, but not their negative counterparts, phagocytose plasminogen activator Pla-expressing Yersinia pestis and Escherichia coli K12 more efficiently than Pla-negative controls. The interactions between Pla-expressing bacteria and DEC-205-expressing transfectants or alveolar macrophages can be inhibited by an anti-DEC-205 antibody. The blockage of the Pla-DEC-205 interaction reduces the dissemination of Yersinia pestis in mice |
| 3.4.23.48 | plasminogen + H2O |
- |
| 3.4.23.48 | plasminogen + H2O |
Pla also expresses a weak coagulase activity |
| 3.4.23.48 | plasminogen + H2O |
activates plasminogen by cleaving the Arg560-Val561 bond |
