EC Number   |
Natural Substrates |
|---|
   3.4.23.45 | amyloid precursor protein + H2O |
the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation |
| 3.4.23.45 | amyloid precursor protein + H2O |
- |
| 3.4.23.45 | amyloid precursor protein + H2O |
able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimers disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP |
| 3.4.23.45 | amyloid precursor protein + H2O |
can cleave the amyloid precursor protein (APP) at the N terminal Asp-1 position of A-beta, preferential cleavage within the A-beta region at Phe19 or Phe20, enzyme function is not consistent with a requirement and function of BACE1 as a beta-secretase in the brain, may act antagonistically to BACE1 |
| 3.4.23.45 | amyloid precursor protein + H2O |
cleavage at the beta site of amyloid precursor protein but preferably between Phe690 and Phe691 or Phe691 and Ala692 |
| 3.4.23.45 | amyloid precursor protein + H2O |
cleavage at the beta-site but more effectively at a different site within A-beta, non-amyloidogenic function suggested |
| 3.4.23.45 | amyloid-beta precursor protein + H2O |
- |
| 3.4.23.45 | beta-amyloid precursor protein APP + H2O |
- |
| 3.4.23.45 | beta-amyloid precursor protein APP + H2O |
cleavage at KLVF-/-FAED and at LVFF-/-AEDV, and with low activity at EVKM-/-DAEF |
| 3.4.23.45 | delta and notch-like epidermal growth factor-related receptor + H2O |
- |
