EC Number   |
Natural Substrates |
|---|
   3.4.23.39 | Hemoglobin + H2O |
- |
| 3.4.23.39 | Hemoglobin + H2O |
enzyme is involved in initial steps of Plasmodium hemoglobin degradation |
| 3.4.23.39 | Hemoglobin + H2O |
during the infection of erythrocytes by the human malaria parasite Plasmodium falciparum, up to 80% of the host cell hemoglobin is degraded to provide amino acids for parasite nutrition. Plasmepsin I and plasmepsin II are believed to be responsible for initiating the catabolic process |
| 3.4.23.39 | Hemoglobin + H2O |
the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34 |
| 3.4.23.39 | Hemoglobin + H2O |
the enzyme participates in the hemoglobin digestive pathway |
| 3.4.23.39 | Hemoglobin + H2O |
the enzyme is involved in degradation of the host cell hemoglobin within the acidic food vacuole of the parasite |
| 3.4.23.39 | Hemoglobin + H2O |
pro-plasmepsin II is transported through the secretory system to cytostomal vacuoles and then is carried along with its substrate hemoglobin to the food vacuole where it is proteolytically processed to mature PMII |
| 3.4.23.39 | plasmepsin 2 + H2O |
PSM2 auto-cleavage after F112 is complete after 20 min in 10 mM citrate pH 4.5 |
| 3.4.23.39 | spectrin + H2O |
- |
| 3.4.23.39 | spectrin + H2O |
the enzyme catalyzes the degradation of spectrin in the erythrocyte membrane cytoskeletron |
