EC Number |
Natural Substrates |
---|
3.4.22.64 | cationic channel subunit transient receptor potential channel 1 + H2O |
i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses |
3.4.22.64 | gasdermin D + H2O |
- |
3.4.22.64 | more |
- |
3.4.22.64 | more |
overexpression induces apoptosis |
3.4.22.64 | more |
phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock |
3.4.22.64 | more |
the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS |
3.4.22.64 | more |
enzyme is involved in cytokine activation |
3.4.22.64 | more |
pro-caspase-11 physically interacts with pro-ICE in cells, the expression of casp-11 is essential for activation of ICE. Caspase-11 is a compinent of ICE complex and is required for the activation of ICE. Important role of ICE and caspase-11 in mediating apoptosis in pathological conditions |
3.4.22.64 | more |
the enzyme may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE |
3.4.22.64 | more |
the enzyme is involved in cytokine activation |