EC Number |
Natural Substrates |
---|
3.4.22.56 | 19 S proteasome + H2O |
caspase-3 specifically cleaves the 19 S component of 26 S proteasome Rpt2, Rpt6, and Rpn2 in skeletal muscle stimulating proteasome activity |
3.4.22.56 | anamorsin + H2O |
specifically cleaved by caspase-3 at DSVD209 L generating 25- and 10-kDa fragments |
3.4.22.56 | beta-catenin + H2O |
processing of beta-catenin, production of a 70000 Da fragment |
3.4.22.56 | beta-N-acetylglucosaminidase + H2O |
cleavage during apoptosis into two fragments during apoptosis, an N-terminal fragment containing the O-GlcNAcase active site and a C-terminal fragment containing a region with homology to GCN5 histone acetyltransferases, mutation D413A abrogates cleavage by caspase-3 both in vitro and in vivo. O-GlcNAcase activity is not affected by caspase-3 cleavage because the N- and C-terminal O-GlcNAcase fragments remain associated after the cleavage |
3.4.22.56 | Bid peptide + H2O |
- |
3.4.22.56 | caspase 9 + H2O |
cleavage by caspase 3 does not result in activation of caspase 9, but enhances apoptosis by alleviating XIAP inhibition of the apical caspase |
3.4.22.56 | cytokeratine 18 + H2O |
caspase-induced cytokeratine 18 cleavage in apoptotic cell populations |
3.4.22.56 | D4-GDI(Rho-GDI 2) + H2O |
differential regulation of the homologous GDP dissociation inhibitors Rho-GDI 1 and D4-GDI during drug-induced apoptosis by proteolysis mediated by caspase-3 |
3.4.22.56 | eIF4G + H2O |
caspase 3 is capable of cleaving eIF4G as part of the translationally active complex eIF4F, thereby inactivating this complex and subsequently causing inhibition of translation in apoptotic cells |
3.4.22.56 | epidermal growth factor receptor + H2O |
cleavage during apoptosis |