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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.4.22.53
alpha-2 spectrin + H2O
-
3.4.22.53
alpha-spectrin + H2O
-
3.4.22.53
aminopeptidase B + H2O
-
3.4.22.53
androgen receptor + H2O
-
3.4.22.53
beta-transducin repeat containing protein + H2O
-
3.4.22.53
calmodulin-dependent protein kinase II deltaB + H2O
angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes
3.4.22.53
casein + H2O
-
3.4.22.53
caspase-3 + H2O
-
3.4.22.53
collapsin response mediator protein-1 + H2O
collapsin response mediator protein-1 is cleaved by calpain-2 at the C-terminus
3.4.22.53
collapsin response mediator protein-2 + H2O
collapsin response mediator protein-2 is cleaved by calpain-2 at the C-terminus
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