EC Number   |
Natural Substrates |
|---|
   3.4.22.48 | Collagen + H2O |
the enzyme cleaves collagen into peptide fragments that can support Staphylococcus aureus growth under nutrient-limited conditions |
| 3.4.22.48 | CXCR2 + H2O |
the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36 |
| 3.4.22.48 | cystatin C + H2O |
specificity of staphopains when interacting with cystatins as natural protein substrates presented |
| 3.4.22.48 | cystatin D + H2O |
specificity of staphopains when interacting with cystatins as natural protein substrates presented |
| 3.4.22.48 | Galectin-3 + H2O |
the enzyme has galectin-3-processing capacity |
| 3.4.22.48 | Galectin-3 + H2O |
the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection |
| 3.4.22.48 | integrin CD11b + H2O |
on phagocytes |
| 3.4.22.48 | kininogen + H2O |
activation of human protein by SspA, kinin generation is responsible for infection associated pain and endema |
| 3.4.22.48 | more |
staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus |
| 3.4.22.48 | more |
staphopain A does not cleave human CXCR1 |
