EC Number   |
Natural Substrates |
|---|
   3.4.22.47 | bradykinin + H2O |
together with gingipain R, gingipain K induces vascular permeability enhancement in human plasma by cleaving bradykinin from high molecular weight kininogen |
| 3.4.22.47 | elafin + H2O |
all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) |
| 3.4.22.47 | Fibrinogen + H2O |
most prominent target among plasma proteins |
| 3.4.22.47 | focal adhesion kinase + H2O |
Kgp is responsible for degradation of integrin-related molecules |
| 3.4.22.47 | Hemoglobin + H2O |
degradation, the enzyme forms a complex with the outer membrane receptor HmuR required for binding and utilization of hemoglobin and hemin, overview |
| 3.4.22.47 | interleukin 8 + H2O |
- |
| 3.4.22.47 | interleukin 8 + H2O |
degradation of human interleukin 8 in Porphyromonas gingivalis-infected human umbilical vein endothelial cells |
| 3.4.22.47 | interleukin-1beta + H2O |
biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain |
| 3.4.22.47 | interleukin-6 + H2O |
biological inactivation and degradation |
| 3.4.22.47 | interleukin-8 + H2O |
biological inactivation and degradation |
