EC Number   |
Natural Substrates |
|---|
   3.4.22.35 | chemokine CCL13 + H2O |
Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response |
| 3.4.22.35 | chemokine CCL2 + H2O |
Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response |
| 3.4.22.35 | chemokine CXCL8 + H2O |
Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response |
| 3.4.22.35 | collagen type 1 + H2O |
- |
| 3.4.22.35 | Fibronectin + H2O |
- |
| 3.4.22.35 | more |
significant pathogenicity factor |
| 3.4.22.35 | more |
role in tissue invasion |
| 3.4.22.35 | more |
appears to be important both for digestion and as a cytotoxic factor |
| 3.4.22.35 | more |
the enzyme can degrade colon cell mucin and destroy epithelial cell layers |
| 3.4.22.35 | more |
the enzyme degrades a number of proteins, including those of the extracellular matrix |
