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Results 1 - 10 of 15

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.21.B39	defensin-1alpha + H2O	KLK5 is capable of processing defensin-1alpha and may be important in vaginal host defense
3.4.21.B39	desmocollin-2 + H2O	-
3.4.21.B39	desmocollin-3 + H2O	-
3.4.21.B39	desmoglein 1 + H2O	-
3.4.21.B39	desmoglein protein 1 + H2O	-
3.4.21.B39	more	involved in ovarian cancer
3.4.21.B39	more	regulation by steroid homones
3.4.21.B39	more	the enzyme is differentially expressed at the mRNA and protein level in diverse malignancies including cancer
3.4.21.B39	more	KLK5 plays a central role in skin desquamation as an initiating activating enzyme in proteolytic cascades formed by kallikreins
3.4.21.B39	more	unregulated KLK5 directly activates proteinase-activated receptor 2 and induces nuclear factor kappaB-mediated overexpression of TSLP, intercellular adhesion molecule 1, tumor necrosis factor alpha, and IL8

Results 1 - 10 of 15

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Release 2023.1 (January 2023)