EC Number   |
Natural Substrates |
|---|
   3.4.21.B27 | human transferrin receptor 1 + H2O |
cleavage at an atypical site KTECER-/-LA |
| 3.4.21.B27 | human transferrin receptor 1 + H2O |
cleavage at an atypical site KTECER-/-LA, in which the P1 Arg100 and P6 Lys95 are critical,.cleavage at Arg100 |
| 3.4.21.B27 | more |
soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor |
| 3.4.21.B27 | more |
the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) |
| 3.4.21.B27 | more |
hemojuvelin is not directly cleaved by the enzyme despite the presence of a RNRR motif. No activity on hepcidin |
| 3.4.21.B27 | preprohepcidin + H2O |
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin |
| 3.4.21.B27 | pro-VEGF-C + H2O |
pro-VEGF-C processing is required for VEGF-C induced tumor antiogenesis and lymphangiogenesis |
