EC Number   |
Natural Substrates |
|---|
   3.4.21.B10 | alpha-synuclein + H2O |
- |
| 3.4.21.B10 | alpha-synuclein + H2O |
recombinant and naturally secreted KLK6 can readily cleave alpha-synuclein fibrils that have the potential for cell-to-cell propagation in a prion-like mechanism |
| 3.4.21.B10 | amyloid precursor proteins + H2O |
enzyme may play a role in development of Alzheimer's disease |
| 3.4.21.B10 | more |
enzyme is involved in breast and ovarian cancer |
| 3.4.21.B10 | more |
regulation by steroid hormones |
| 3.4.21.B10 | more |
the enzyme activates G-protein coupled protease activated receptors |
| 3.4.21.B10 | plasminogen + H2O |
the enzyme is regulated by an autoactivation/autoinactivation mechanism. Mature hK67 displays a trypsin-like activity against human plasminogen, the putative physiological substrate |
| 3.4.21.B10 | polypeptide + H2O |
- |
| 3.4.21.B10 | proform protease activated receptor 1 + H2O |
- |
| 3.4.21.B10 | proform protease activated receptor 2 + H2O |
- |
