EC Number   |
Natural Substrates |
|---|
   3.4.21.93 | glucose-dependent insulinotropic polypeptide precursor + H2O |
PC1/3 is essential for pro-GIP processing |
| 3.4.21.93 | more |
biosynthesis of peptide hormones by processing of larger precursors |
| 3.4.21.93 | more |
cleaves polypeptide hormones and many proteins at specific sites |
| 3.4.21.93 | more |
constitutive secretory pathway |
| 3.4.21.93 | more |
implicated in processing of proproteins in the secretory pathway, synthesized as a zymogen, cleaves his own profragment in the endoplasmic reticulum |
| 3.4.21.93 | more |
key enzyme capable of processing a variety of prohormones to their bioactive forms |
| 3.4.21.93 | more |
regulated secretory pathway |
| 3.4.21.93 | more |
the enzyme is involved in the regulated secretory pathway in neuroendocrine cells |
| 3.4.21.93 | more |
the enzyme is involved in the regulated secretory pathway in neuroendocrine cells, the enzyme activity is regulated by the PC1-propeptide and by proSAAS CT peptide |
| 3.4.21.93 | more |
the potential cleavage site delineating the pro-domain, Arg102-Xaa-Lys-Arg, is remarkably conserved among different species and is preceded by two preserved Gln residues located in positions 96 and 97 |
