EC Number   |
Natural Substrates |
|---|
   3.4.21.7 | ADAMTS13 + H2O |
inactivation |
| 3.4.21.7 | amyloid-beta + H2O |
the plasmin pathway is induced by aggregated amyloid-beta, which can lead to amyloid-beta degradation and inhibition of amyloid-beta actions |
| 3.4.21.7 | beta2-glycoprotein I + H2O |
in human plasma beta2-glycoprotein I is proteolytically cleaved by plasmin in its domain V (nicked beta2GPI), resulting in binding to plasminogen |
| 3.4.21.7 | casein + H2O |
- |
| 3.4.21.7 | chromogranin A + H2O |
the product hCgA-(360-373) is a bioactive fragment that inhibits nicotinic-mediated catecholamine release. The plasminogen/plasmin system through its interaction with chromogranin A may play a major role in catecholaminergic function |
| 3.4.21.7 | complement component C3 + H2O |
- |
| 3.4.21.7 | complement component C3a + H2O |
- |
| 3.4.21.7 | complement component C3b + H2O |
the enzyme inactivates the C3b molecule for complement C3b amplification |
| 3.4.21.7 | complement component C3b + H2O |
cleavage by plasmin produces bands of 46000 Da, 40000 Da, 30000 Da and 17000 Da |
| 3.4.21.7 | complement component C5 + H2O |
cleavage by plasmin produces bands of approximately 41000 Da and 30000-28000 Da |
