EC Number   |
Natural Substrates |
|---|
   3.4.21.6 | activated factor VIII + H2O |
proteolytic inactivation |
| 3.4.21.6 | factor VIII + H2O |
factor Xa proteolytically activates Factor VIII by cleaving P1 residues Arg372, Arg740, and Arg1689. Factor Xa also catalyzes inactivating cleavages that occur on a slower time scale than the activating ones |
| 3.4.21.6 | factor VIII + H2O |
proteolytic activation by removal of the B domain |
| 3.4.21.6 | more |
enzyme is involved in the coagulation cascade |
| 3.4.21.6 | more |
enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview |
| 3.4.21.6 | more |
properties of and indications for different enzyme inhibitors, overview, the enzyme is responsible for clot-associated procoagulant activity, enzyme inhibition lead to reduced platelet deposition and aggregation at thrombic sites |
| 3.4.21.6 | more |
the enzyme is regulated by sequential occupancy of a pair of linked lipid binding sites, each of which have different minimum ligand structural requirements to induce structural changes |
| 3.4.21.6 | more |
the enzyme is responsible for clot-associated procoagulant activity |
| 3.4.21.6 | more |
factor Xa can induce mesangial cell proliferation through the activation of extracellular regulated kinase via protease-activated receptor 2 in mesangial cells. Protease-activated receptor 2 may play a crucial role in the cell proliferation induced by factor Xa |
| 3.4.21.6 | more |
blood clot elongation is regulated by factor Xa formation by intrinsic tenase, i.e. factor VIIa and tissue factor complex, coagulation factors from plasma bind to tissue factor TF-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets, overview |
