EC Number |
Natural Substrates |
---|
3.4.17.21 | folyl-poly-gamma-glutamate + H2O |
cleavage of the C-terminal glutamate |
3.4.17.21 | more |
enzyme inhibition depresses mossy fiber-CA3 synaptic transmission |
3.4.17.21 | more |
the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview |
3.4.17.21 | more |
intestinal absorption of polyglutamyl folates involves cleavage of the glutamate side chain by FGCP |
3.4.17.21 | more |
cross-linking of cell surface PSMA with specific antibodies activates the small GTPases RAS and RAC1 and the MAPKs p38 and ERK1/2 in prostate carcinoma LNCaP cells via NF-kappaB activation, overview. Proliferation of LNCaP cells is inducible by interleukin-6, CCL5 or by cross-linking of PSMA |
3.4.17.21 | more |
PSMA is highly homologous to N-acetylated alpha-linked acidic dipeptidase, NAALADase |
3.4.17.21 | more |
PSMA-targeted photodynamic therapy on cytoskeletal networks in prostate cancer cells results in rapid disruption of microtubules (alpha-/beta-tubulin), microfilaments (actin), and intermediate filaments (cytokeratin 8/18) in the cytoplasm of LNCaP cells. The collapse of cytoplasmic microtubules and the later nuclear translocation of alpha-/beta-tubulin are the most dramatic alternation, overview |
3.4.17.21 | N-acetyl-alpha L-aspartyl-L-glutamate + H2O |
- |
3.4.17.21 | N-acetyl-alpha-L-aspartyl-L-glutamate + H2O |
- |
3.4.17.21 | N-acetyl-alpha-L-aspartyl-L-glutamate + H2O |
enzyme inhibition reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion traumatic brain injury |