EC Number   |
Natural Substrates |
|---|
   3.4.13.9 | Gly-Pro |
- |
| 3.4.13.9 | Gly-Pro + H2O |
- |
| 3.4.13.9 | melphalan + H2O |
prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan, overview |
| 3.4.13.9 | more |
the enzyme is involved in collagen metabolism |
| 3.4.13.9 | more |
the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor |
| 3.4.13.9 | more |
the enzyme plays an important role in recycling of proline for collagen synthesis and cell growth, regulation by phosphorylation and dephosphorylation |
| 3.4.13.9 | more |
alpha-ketoglutarate increases activities of prolidase, which is known to play an important role in collagen metabolism, in fibroblasts, N-benzyloxycarbonyl-L-proline, a prolidase inhibitor, inhibits procollagen synthesis by alpha-ketoglutarate in fibroblasts, alpha-ketoglutarate diminishes UVB-induced wrinkle formation by increasing collagen production, through a pathway that involves prolidase activation, regulation, overview |
| 3.4.13.9 | more |
interleukin-1beta action and inhibition, resulting in increase in beta1-integrin receptor, NF-kappaB expressions, and increase in phosphorylation of FAK, does deregulate the collagen metabolism, but does not influence the prolidase activity, while metalloproteinase MMP-2 and MMP-9 activities are activated, overview |
| 3.4.13.9 | more |
lack of prolidase I leads to prolidase deficiency, a disease characterized by intractable skin lesions, recurrent respiratory infections, and mental retardation, physiologic roles of prolidase isoenzymes, PD I functions by way of an intestinal peptide carrier, which may be regulated by the uptake of various iminodipeptides, intestinal PD II also participates in absorption of proline and other amino acids early in life, overview |
| 3.4.13.9 | more |
PepQ is a cytoplasmic prolidase that specifically liberated proline from dipeptides with increased activity under high salt conditions, PepX, a X-prolyl-dipeptidyl aminopeptidase, and PepI, a iminopeptidase, are unaffected, overview |
