EC Number |
Natural Substrates |
---|
3.1.3.4 | 1,2-diacylglycerol 3-phosphate + H2O |
- |
3.1.3.4 | 1,2-dioleoyl-sn-glycerol-3 phosphate |
insulin and epinephrine control lipin 1 primarily by changing localization rather than intrinsic PAP activity, overview |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
- |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
dephosphorylation of these lipids terminates their signaling actions and generates products with additional biological activities or metabolic fates, overview |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
key enzyme in the regulation of lipid synthesis, it PAP generates a pool of diacylglycerol used for protein kinase C activation, and attenuates the signaling functions of phosphatidic acid |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
key enzyme in the regulation of lipid synthesis, PAP generates a pool of diacylglycerol used for protein kinase C activation, and attenuates the signaling functions of phosphatidic acid |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme to catalyze the penultimate step in triglyceride synthesis. Lipin 2 plays an important role as a hepatic PAP-1 enzyme |
3.1.3.4 | a 3-sn-phosphatidate + H2O |
lipin-1 is negatively regulated by phosphorylation during mitosis |