EC Number   |
Natural Substrates |
|---|
   3.1.26.4 | 12 base pair RNA-DNA hybrid + H2O |
- |
| 3.1.26.4 | DNA-RNA duplex + H2O |
specific cleavage of the RNA part |
| 3.1.26.4 | DNA-RNA hybrid + H2O |
- |
| 3.1.26.4 | DNA-RNA hybrid + H2O |
strategy for regulating RNA digestion by RNase H by using a light-activated DNA hairpin, overview |
| 3.1.26.4 | DNA-RNA hybrid + H2O |
in the pause of minus strang synthesis, RNAse H degrades the RNA template, with the exception of the polypurine tract sequence, immediately upstream of U3, which serves as a primer for plus-strand synthesis |
| 3.1.26.4 | DNA-RNA hybrid duplex + H2O |
- |
| 3.1.26.4 | more |
presence of intrinsic cell-type specific factors affecting the activity and localization of type 2 enzyme |
| 3.1.26.4 | more |
the enzyme is regulated by a unique redox switch formed by adjacent Cys147 and Cys148 |
| 3.1.26.4 | more |
the enzyme is required for kinetoplast DNA replication in the mitochondrion, the RNase HIIC is essential for growth of promastigotes and amastigotes |
| 3.1.26.4 | more |
member of the nucleotidyl-transferase superfamily and endo-nucleolytically cleaves the RNA portion in RNA/DNA hybrids and removes RNA primers from Okazaki fragments. Enzyme binds RNA and DNA duplexes but is unable to cleave either |
