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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.1.1.43
an alpha-aminoacid ester + H2O
-
3.1.1.43
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alpha-amino acid ester hydrolase catalyzes the synthesis of beta-lactam antibiotics, e.g. cefadroxil, cefprozil and cefatrizine, containing an alpha-amino group with decreased activity toward antibiotics with a para-hydroxyl group
3.1.1.43
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substrate specificity of the enzyme, which hydrolyzes valacyclovir and some other aciclovir esters with an alpha-amino group in the acyl radical
3.1.1.43
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the enzyme synthesizes artificial cephalosporins by acylating the 7-amino group of cephalosporin nuclei with different alpha-amino acid esters
3.1.1.43
valacyclovir + H2O
-
3.1.1.43
valacyclovir + H2O
stereospecific reaction
3.1.1.43
valganciclovir + H2O
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